Morphogenesis of the CNCs (green) and endoderm (red) in developing zebrafish embryos (19-30 hpf). A control embryo is on the left and an embryo, where Bmp signaling has been block from 10-18 hpf using a small chemical inhibitor, is on the right.
Loss of Bmp signaling on craniofacial development. A control embryo is on the left and an embryo, where Bmp signaling has been block using a heat-shock inducible dominate negative Bmp receptor transgene, is on the right.
Endoderm pouch morphology. Alcama in the endoderm is labeled with the Zn-8 antibody (red) and F-actin is labeled with phalloidin (green).
Dorsal view of the morphology of the pharyngeal arches. The CNCs are green and endoderm is red
The impact of the au15 - ethanol interaction on craniofacial development. 72 hpf WT embryo on the left. An ethanol-exposed, 72hpf au15 embryo is center and the same ethanol-exposed au15 embryo stained with alcian/alizarin at 5 dpf.
Ventral view of the oral opening in a 48 hpf WT embryo. Green is the periderm and orange is the Bmp Response.
A 3-eyed embryo. An alcian/alizarin stained embryo at 5 dpf that has 3 eyes, 2 palates, and 1 jaw.
The head of a 1 dpf embryo which has the periderm labeled in green.